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Subsample Definitions

SubsampleDesignComponent%YearsDetailRequired Operations
6% CT Blood
(Form 100)
CohortHT
DM
(CT)
8.6%
4.3%
(~6% CT cohort)
0, 1, 3, 6, 9Stratified by CC, hyst (HT), race; oversampling of minorities with goal of equity across clinics (same subsample as Form 80 [for hip/waist], and Form 38- Daily Life.  DM subsample same as 4DFR)Blood analyzed for 20 ‘core’ analytes: micronutrients, glucose, insulin, lipids
FFQ
(Form 60)
one-time

Rotating cross-sectional
DM

30%

33%
2

Annually after year 2
Stratified by CCDesigned so that each participant is scheduled to complete an FFQ every 3 years after year 2
4DFR
(Form 62)
CohortDM4.6%0, 1Overlap with blood subsample in DM4DFRs collected, documented, and analyzed on subsample
24 Hr RecallRepeated, cross-sectional

Cohort
DM



DM
1%



4.6%
Annually



3, 6, 9
Selected annually



Same subsample as 4DFR
24 Hr administered centrally



Note:  24 Hr replaced the 4DFR after year 1
Endometrial Aspiration
(Form 82)
CohortHT with uterus5%3, 6, 9Stratified by CC
Cognitive Function
(Form 39)
CohortHT > 65 yrs old25%0, 1, 3, 6, 9Stratified by CC
Daily Life
(Form 38)
CohortHT
DM
8.6%
4.3%
3, 6, 9Stratified by CC, hyst (HT), race; oversampling of minorities with goal of equity across clinics (same as blood subsample)
Functional Status (Form 90)CohortHT and DM  > 65 yrs old
 
25%3, 6, 9Stratified by CC, selected independently of Cognitive Function subsample
OS-MPS
 (Measurement Precision Study)
one-timeOS1%0Stratified by CC, age, race/ethnicity, subject to consentRepeat selected baseline measurements at 3 months, including blood sample
Waist/Hip Circumferences (Form 80)CohortHT
 DM
 (CT)
8.6%
 4.3%
 (~6% CT cohort)
0, 1, 3, 6, 9Same as Blood (Form 100)
BMDCohortCT and OSAll participants randomized/enrolled at 3 clinical centers, or about 6-7% of total WHIBaseline, Y3, Y6, Y9; additional collection at Y1 for CTWhole body, Hip, and Spine scans at each contact