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About WHI

The Women’s Health Initiative (WHI) is a long-term national health study funded by the National Heart, Lung, and Blood Institute, or NHLBI. The original WHI study began in the early 1990s and concluded in 2005. Since 2005, the WHI has continued as Extension Studies, which are annual collections of health updates and outcomes in active participants. The second Extension Study enrolled 93,500 women in 2010 and follow-up of these women continues through another extension that will conclude in 2020. NHLBI intends to fund the next Extension Study for the follow-up of WHI participants through 2027.

As with the original WHI study, the main areas of research are cardiovascular disease, cancers, and osteoporotic fractures. While WHI continues to focus on strategies to prevent the major causes of death, disability, and frailty in older women, the breadth and richness of the WHI data allow for the exploration and investigation of many more research questions on women’s health and aging.

To learn more about the original WHI study that began in the early 1990’s, including specific details about the three clinical trials and the observational study, visit the WHI program page on the NHLBI website.

About WHI Extension Participants

Journey through WHI’s history

WHI Leadership – Steering Committee

An organizational chart provides further information detailing the roles of individual WHI Steering Committee members. Please continue reading the next section to learn more about former PIs and key contributors to the Women’s Health Initiative over the past three decades.

Study Organization

The WHI study consisted of 40 Clinical Centers, several with additional satellite locations, during the recruitment and active intervention phase of WHI (1993-2005). During the WHI Extension Studies, the Clinical Centers were consolidated into 10 Regional Centers in 2010, as shown on the map. The WHI Clinical Coordinating Center (CCC) is located at the Fred Hutchinson Cancer Research Center, in Seattle, WA. The tables below show the investigator names and locations of the original Clinical Centers and the current Regional Centers. Visit the Contacts page for CCC and Regional Center contact information.

Current Study Organization

WHI Project Office

InstitutionLocationProject Officer
National Heart, Lung, and Blood InstituteBethesda, MDJacques Rossouw, M.D., 1993-2014
Shari Ludlam, M.P.H., 2014-

WHI Clinical Coordinating Center

InstitutionLocationPrincipal Investigator
Fred Hutchinson Cancer Research CenterSeattle, WARoss Prentice, Ph.D. 1993-2010
Garnet Anderson, Ph.D. 2010-

WHI Regional Centers

RegionRegional Center or
Regional Center Site
InstitutionPrincipal Investigator
NortheastBuffalo, NY
Boston, MA
University at Buffalo
Brigham and Women’s Hospital
Jean Wactawski-Wende, Ph.D.
JoAnn Manson, M.D., Dr.P.H.
SoutheastWinston-Salem, NCWake Forest UniversityMara Vitolins, Dr.P.H.
MidwestColumbus, OHThe Ohio State UniversityRebecca Jackson, M.D.
WestStanford, CAStanford UniversityMarcia Stefanick, Ph.D.
CCCSeattle, WAFred Hutchinson Cancer
Research Center
Garnet Anderson, Ph.D.

WHI Collaborating Centers

InstitutionLocationPrincipal Investigator
Fisher BioServicesRockville, MDOguz Mandaci
University of North Carolina, Chapel HillChapel Hill, NCWayne Rosamond, Ph.D

Original Clinical Centers

RegionInsitutionLocationPrincipal Investigator
NortheastAlbert Einstein College of MedicineBronx, NY​Sylvia Wassertheil-Smoller, Ph.D. 1994-2010
NortheastBrigham and Women’s HospitalBoston, MAJoAnn Manson, M.D., Dr.P.H. 1994-2010
NortheastGeorge Washington University  Washington, DC   Valery Miller, M.D. 1994-1996
Judy Hsia 1996-2005
Valery Miller 2005-2007
Lisa Martin, M.D., F.A.C.C. 2008-2010
NortheastMedStar Research InstituteWashington, D.C.Barbara Howard, Ph.D. 1994-2015
NortheastMemorial Hospital of Rhode IslandPawtucket, RI Annlouise Assaf, Ph.D. 1993-2008
Charles Eaton, M.D. 2008-2010
NortheastState University of New York, BuffaloBuffalo, NY Maurizio Trevisan, M.D. M.S. 1994-2003
Jean Wactawski-Wende, Ph.D. 2003-2010
NortheastResearch Foundation SUNY, Stony BrookStony Brook, NYDorothy Lane, M.D., M.P.H. 1994-2010
NortheastUniversity of MassachusettsWorcester, MAJudith Ockene, Ph.D. 1994-2010
NortheastUniversity of Medicine and DentistryNewark, NJNorman Lasser, M.D., Ph.D. 1993-2010
SoutheastBaylor College of Medicine  Houston, TX   John Foreyt, Ph.D. 1994-1998
Jennifer Hayes, Ph.D. 1998-2007
Aleksandar Rajkovic, M.D., Ph.D. 2007-2009
Haleh Sangi-Haghpeykar, Ph.D. 2009-2010
SoutheastEmory University  Atlanta, GA   Dallas Hall, M.D., 1993-1998
Sally McNagry, M.D., 1998-1999
Nelson Watts, M.D.,  1999-2001
Larry Phillips, M.D.,  2001-2010
SoutheastUniversity of Alabama at BirminghamBirmingham, AL Albert Oberman, M.D., M.P.H., 1993-2000
Cora Lewis, M.D., M.S.P.H., 2000-2010
SoutheastUniversity of FloridaGainesville / Jacksonville, FLMarian Limacher, M.D. 1994-2019
SoutheastUniversity of MiamiMiami, FL Marianna Baumn, Ph.D., 1994-1999
Mary Jo O’Sullivan, M.D., 1999-2010
SoutheastUniversity of North Carolina, Chapel Hill Chapel Hill, NC  David Sheps, M.D., N.S.P.H. 1994-1998
Barbara Hulka 1998-1999
Gerardo Heiss, M.D. M.P.H. 1999-2010
SoutheastUniversity of TexasSan Antonio, TX Robert Schenken, M.D. 1994-2003
Robert Brzyski, M.D. 2003-2010
Haleh Sangi-Haghpeykar, Ph.D. 2010
SoutheastUniversity of TennesseeMemphis, TN William Applegate, M.D. 1993-1999
Karen Johnson, M.D., M.P.H. 1999-2010
SoutheastWake Forest University Winston-Salem/ Greensboro, NC Gregory Burke, M.D., M.S. 1993-1998; 2002-2004
Electra Paskett, Ph.D. 1998-2002
Denise Bonds, M.D. 2004-2007
Mara Vitolins, Dr.P.H. 2007-2010
Sally Shumaker, Ph.D. 2010-2019
MidwestMedical College of WisconsinMilwaukee, WIJane Kotchen, M.D., M.P.H. 1994-2010
MidwestNorthwestern UniversityChicago/ Evanston, ILPhilip Greenland, M.D. 1993-2000
Linda Van Horn, Ph.D., RD 2000-2010
MidwestOhio State UniversityColumbus, OHRebecca Jackson, M.D. 1994-2010
MidwestRush University Medical CenterChicago, IL Henry Black, M.D. 1993-2007
Lynda Powell, Ph.D., M.Ed. 2000-2010
MidwestUniversity of Cincinnati Cincinnati, OH  James Liu, M.D. 1994-2001
Margery Gass, M.D. 2001-2009
Michael Thomas, M.D. 2009-2010
MidwestUniversity of IowaIowa City/ Bettendorf, IARobert Wallace, M.D. 1993-2010
MidwestUniversity of MinnesotaMinneapolis, MN Richard Grimm, M.D. 1993-2001
Karen Margolis, M.D. 2001-2010
MidwestUniversity of WisconsinMadison, WI Catherine Allen, Ph.D. 1994-2004
Gloria Sarto, M.D. 2004-2010
MidwestUniversity of PittsburghPittsburgh, PALewis Kuller, M.D., Dr.P.H. 1993-2018
MidwestWayne State UniversityDetroit, MI Susan Hendrix, D.O. 1994-2008
Michael Simon, M.D. 2008-2010
WestFred Hutchinson Cancer Research CenterSeattle, WA Maureen Henderson, M.D., Dr.P.H. 1993-1999
Shirley Beresford, Ph.D. 1999-2010
WestKaiser Foundation Research InstituteOakland, CA Robert Hiatt, M.D., Ph.D. 1994-1998
Bette Caan, Ph.D. 1998-2010
WestOregon Health & Science University   Portland, OR    Barbara Valanis, Dr.P.H. 1994-1999
Cheryl Ritenbaugh, Ph.D. 1999-2004
Evelyn Whitlock, M.D. 2004-2008
Yvonne Michael, Sc.D. 2008-2010
Erin LeBlanc, M.D. 2010
WestStanford UniversityStanford, CAMarcia Stefanick, Ph.D. 1994-2010
WestUniversity of Arizona  Tucson/ Phoenix, AZ  Thomas Moon, Ph.D. 1993-1994
Cheryl Ritenbaugh, Ph.D. 1994-1998
Tamsen Bassford, M.D. 1998-2005
Cyndi Thomson, Ph.D., R.D. 2005-2010
WestUniversity of California, Los AngelesTorrance, CARowan Chlebowski, M.D., Ph.D. 1994-2010
WestUniversity of HawaiiHonolulu, HIJ. David Curb, M.D. 1994-2010
WestUniversity of California, DavisSacramento, CAJohn Robbins, M.D. 1993-2010
WestUniversity of California, IrvineIrvine, CA Frank Meyskens, Jr., M.D. 1994-1999
Allan Hubbell, M.D. 1999-2010
WestUniversity of California, Los AngelesLos Angeles, CA Howard Judd, M.D. 1994-2006
Lauren Nathan, M.D. 2006-2010
WestUniversity of California, San DiegoLaJolla, CARobert Langer, M.D. M.P.H. 1994-2005
Andrea LaCroix Ph.D. 2005-2010
WestUniversity of NevadaReno, NV Sandra Daugherty, M.D., Ph.D. 1994-2000
Robert Brunner, Ph.D. 2000-2010